Structure of PDB 8ifl Chain B

Receptor sequence

>8iflB (length=427) Species: 1393122 (Thermoflavifilum thermophilum) [Search protein sequence]

MKELIYIEEPSILFAHGQKCTDPRDGLALFGPLNQIYGIKSGVVGTQKGL
QIFKSYLDKIQKPIYNHNNITRPMFPGFEAVFGCKWESQNIVFKEITKRT
YDLVTLFNDKIITANKNDEERVDVWFVIVPEYDAQFHDQLKARLLEHTIP
TQILRESTLAWRDFKNTFGAPIRDFSKIEGHLAWTISTAAYYKAGGKPWK
LGGVCYLGLVYKKIQNACCAAQMFLDNGDGTVFKGEVGPWYNPEKGEYHL
KPKEAKALLTQALESYKEQNKSYPKEVFIHARTRFNDEEWNAFNEVTPKN
TNLVGVTITKSKPLKLYKTEGAFPIMRGNAYIVDEKKAFLWTLGFVPKLQ
STLSMEVPNPIFIEINKGEAEIQQVLKDILALTKLNYNACIYADGEPVTL
RFANKIGEILTASTEIKTPPLAFKYYI

3D structure

PDB

8ifl Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system.

Chain

Resolution

3.11 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	B	Y202 D203 A204 F206 H207 K211 Q222 I223 L224 R225 T228 F245 I248 L252 T255 I256 K325 G326 K395 L423 S434 M435 N439 N468 A469 D474 G475 R481 I507	Y132 D133 A134 F136 H137 K141 Q152 I153 L154 R155 T158 F175 I178 L182 T185 I186 K245 G246 K315 L343 S354 M355 N359 N388 A389 D394 G395 R401 I427
BS02	dna	B	H67 N68 I70 R72 Y285 K286 Y328 R362 T363 R364 F403 S431 T432	H67 N68 I70 R72 Y211 K212 Y248 R282 T283 R284 F323 S351 T352
BS03	MG	B	N468 I507	N388 I427

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding

View graph for
Molecular Function

External links

PDB	RCSB:8ifl, PDBe:8ifl, PDBj:8ifl
PDBsum	8ifl
PubMed	37932528
UniProt	A0A1I7NFD7

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