Structure of PDB 8ifk Chain B

Receptor sequence

>8ifkB (length=409) Species: 1393122 (Thermoflavifilum thermophilum) [Search protein sequence]

MKELIYIEEPSILFAHGQKCTDPRDGLALFGPLNQIYGIKSGVVGTQKGL
QIFKSYLDKIQKPIYNHNNITRPMFPGFEAVFGCKWESQNIVFKEITTYD
LVTLFNDKIITANRVDVWFVIVPEEDAQFHDQLKARLLEHTIPTQILRES
TLAWRDFKNTFGAPIRDFSKIEGHLAWTISTAAYYKAGGKPWKLGDIRPG
VCYLGLVYKKIEQNACCAAQMFLGPWYNPEKGEYHLKPKEAKALLTQALE
SYKEQNKSYPKEVFIHARTRFNDEEWNAFNEVTPKNTNLVGVTITKSKPL
KLYKTEGAFPIMRGNAYIVDEKKAFLWTLGFVPKLQSTLSMEVPNPIFIE
INKGEAEIQQVLKDILALTKLNYNACIYADGEPVTLRFANKIGEILTAST
PPLAFKYYI

3D structure

PDB

8ifk Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system.

Chain

Resolution

2.54 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	B	D203 A204 F206 H207 K211 Q222 I223 L224 R225 T228 F245 H251 L252 T255 I256 K395 L423 S434 M435 E436 P438 N439 N466 N468 A469 I471 D474 G475 R481 I507	D126 A127 F129 H130 K134 Q145 I146 L147 R148 T151 F168 H174 L175 T178 I179 K301 L329 S340 M341 E342 P344 N345 N372 N374 A375 I377 D380 G381 R387 I409
BS02	dna	B	H67 N68 T71 R72 D244 F245 K247 I248 Y285 K286 K287 Y328 R362 T363 R364 A402 F403 T432 L433 S434 M435	H67 N68 T71 R72 D167 F168 K170 I171 Y208 K209 K210 Y234 R268 T269 R270 A308 F309 T338 L339 S340 M341
BS03	MG	B	N468 I507	N374 I409

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding

View graph for
Molecular Function

External links

PDB	RCSB:8ifk, PDBe:8ifk, PDBj:8ifk
PDBsum	8ifk
PubMed	37932528
UniProt	A0A1I7NFD7

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