Structure of PDB 8iam Chain B

Receptor sequence
>8iamB (length=555) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
YTRVPLCEPEELPDDIQKENEYGTLDSPGHLYQVKSRHGKPLPEPVVDTP
PYYISLLTYLNYLILIILGHVHDFLGMTFQKNKHLDLLEHDGLAPWFSNF
ESFYVRRIKMRIDDCFSRPTTGVPGRFIRCIDRISHNINEYFTYSGAVYP
CMNLSSYNYLGFAQSKGQCTDAALESVDKYSIQSGGPRAQIGTTDLHIKA
EKLVARFIGKEDALVFSMGYGTNANLFNAFLDKKCLVISDELNHTSIRTG
VRLSGAAVRTFKHGDMVGLEKLIREQIVLGQPKTNRPWKKILICAEGLFS
MEGTLCNLPKLVELKKKYKCYLFIDEAHSIGAMGPTGRGVCEIFGVDPKD
VDILMGTFTKSFGAAGGYIAADQWIIDRLRLDLTTVSYSESMPAPVLAQT
ISSLQTISGEICPGQGTERLQRIAFNSRYLRLALQRLGFIVYGVADSPVI
PLLLYCPSKMPAFSRMMLQRRIAVVVVAYPATPLIESRVRFCMSASLTKE
DIDYLLRHVSEVGDKLNLKSNSGKSSYDGKRQRWDIEEVIRRTPEDCKDD
KYFVN
3D structure
PDB8iam Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide.
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.50: serine C-palmitoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B H250 D331 A333 H334 T365 K366 H244 D325 A327 H328 T359 K360
BS02 Z1T B I72 H76 Y110 I66 H70 Y104
Gene Ontology
Molecular Function
GO:0004758 serine C-palmitoyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0009058 biosynthetic process
GO:0030148 sphingolipid biosynthetic process
GO:0046512 sphingosine biosynthetic process
GO:0046513 ceramide biosynthetic process
GO:0090156 intracellular sphingolipid homeostasis
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0017059 serine palmitoyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iam, PDBe:8iam, PDBj:8iam
PDBsum8iam
PubMed38285738
UniProtP40970|LCB2_YEAST Serine palmitoyltransferase 2 (Gene Name=LCB2)

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