Structure of PDB 8i91 Chain B

Receptor sequence
>8i91B (length=579) Species: 9606 (Homo sapiens) [Search protein sequence]
RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVE
GMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNV
INAWAFWYLFHSFQDPLPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTL
NISPSLQENGGVQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPY
CVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWINAATQIFFSLGL
GFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATF
NYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQ
IKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGI
GSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGN
YWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWY
WKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAY
ALAVIGLLVASSTMCIPLAALGTFVQRRL
3D structure
PDB8i91 Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B 0 AT1 and ACE2-SIT1.
ChainB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PRO B Y21 G24 Y102 F250 S251 S406 Y17 G20 Y98 F246 S247 S402
Gene Ontology
Molecular Function
GO:0005298 proline:sodium symporter activity
GO:0005515 protein binding
GO:0015171 amino acid transmembrane transporter activity
GO:0015175 neutral L-amino acid transmembrane transporter activity
GO:0015188 L-isoleucine transmembrane transporter activity
GO:0015193 L-proline transmembrane transporter activity
GO:0015199 amino-acid betaine transmembrane transporter activity
GO:0015293 symporter activity
GO:0015370 solute:sodium symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006865 amino acid transport
GO:0015816 glycine transport
GO:0015824 proline transport
GO:0015838 amino-acid betaine transport
GO:0035725 sodium ion transmembrane transport
GO:0089718 amino acid import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1903804 glycine import across plasma membrane
GO:1903806 L-isoleucine import across plasma membrane
GO:1904271 L-proline import across plasma membrane
GO:1905647 proline import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i91, PDBe:8i91, PDBj:8i91
PDBsum8i91
PubMed37684251
UniProtQ9NP91|S6A20_HUMAN Sodium- and chloride-dependent transporter XTRP3 (Gene Name=SLC6A20)

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