Structure of PDB 8i8f Chain B

Receptor sequence
>8i8fB (length=239) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
RPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVR
DGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDA
LHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLK
VFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAA
SARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR
3D structure
PDB8i8f Crystal structure of NDM-1 at pH5.5 (Succinate) in complex with hydrolyzed compound 1
ChainB
Resolution1.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OL6 B P68 G69 F70 P37 G38 F39
BS02 ZN B H120 H122 H189 H89 H91 H158
BS03 ZN B D124 C208 H250 D93 C177 H219
BS04 OL6 B V73 W93 H122 Q123 D124 H189 C208 K211 G219 N220 H250 V42 W62 H91 Q92 D93 H158 C177 K180 G188 N189 H219
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8i8f, PDBe:8i8f, PDBj:8i8f
PDBsum8i8f
PubMed38336327
UniProtE9NWK5

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