Structure of PDB 8i2b Chain B

Receptor sequence
>8i2bB (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
ADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIP
DFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVS
QNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKAT
GRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQI
RPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHL
GLEIPAWDGPRVLERALPPLPRPPTPKLE
3D structure
PDB8i2b The SIRT6 in complex with inhibitor 7702
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 O5L B I61 P62 F64 V70 E74 M157 I49 P50 F52 V58 E62 M145
BS02 AR6 B G52 G54 T57 D63 F64 R65 Q113 H133 G214 T215 S216 I219 N240 L241 Q242 V258 G40 G42 T45 D51 F52 R53 Q101 H121 G195 T196 S197 I200 N221 L222 Q223 V239
BS03 ZN B C141 C144 C166 C129 C132 C154
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:8i2b, PDBe:8i2b, PDBj:8i2b
PDBsum8i2b
PubMed
UniProtQ8N6T7|SIR6_HUMAN NAD-dependent protein deacylase sirtuin-6 (Gene Name=SIRT6)

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