Structure of PDB 8i02 Chain B

Receptor sequence
>8i02B (length=369) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence]
KKVSYFYDEDVGNYHYGPQHPMKPHRVRMVHNLVVNYNLYEKLNVITPVR
ATRNDMTRCHTDEYIEFLWRVTPDTMEKFQPHQLKFNVGDDCPVFDGLYE
FCSISAGGSIGAAQELNSGNAEIAINWAGGLHHAKKREASGFCYVNDIAL
AALELLKYHQRVLYIDIDVHHGDGVEEFFYTTDRVMTCSFHKFGEYFPGT
GHIKDTGIGTGKNYAVNVPLRDGIDDESYESVFKPVISHIMQWFRPEAVI
LQCGTDSLAGDRLGCFNLSMKGHSMCVDFVKSFNLPMICVGGGGYTVRNV
ARVWTYETGLLAGEELDENLPYNDYLQYYGPDYKLNVLSNNMENHNTRQY
LDSITSEIIENLRNLSFAP
3D structure
PDB8i02 Two assembly modes for SIN3 histone deacetylase complexes.
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D173 H175 D168 H170
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0031078 histone H3K14 deacetylase activity
GO:0032129 histone H3K9 deacetylase activity
GO:0033558 protein lysine deacetylase activity
GO:0034739 histone H4K16 deacetylase activity
GO:0140937 histone H4K12 deacetylase activity
GO:0180032 histone H4K5 deacetylase activity
GO:0180033 histone H4K48 deacetylase activity
Biological Process
GO:0006325 chromatin organization
GO:0010468 regulation of gene expression
GO:0031507 heterochromatin formation
GO:0040029 epigenetic regulation of gene expression
GO:0045815 transcription initiation-coupled chromatin remodeling
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0032221 Rpd3S complex
GO:0033698 Rpd3L complex
GO:0070210 Rpd3L-Expanded complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i02, PDBe:8i02, PDBj:8i02
PDBsum8i02
PubMed37076472
UniProtO59702|CLR6_SCHPO Histone deacetylase clr6 (Gene Name=clr6)

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