Structure of PDB 8hx6 Chain B

Receptor sequence

>8hx6B (length=651) Species: 54571 (Streptomyces venezuelae)

GRHMRTLLIDNYDSFTHNLFQYIGEATGQPPVVVPNDADWSRLPVEDFDA
IVVSPGPGISRRAITDSGLPVLGVCLGIAQLFGGTVGLAPEPMHGRVSEV
RHTGEDVFRGLPSPFTAVRYHSLAATDLPDELEPLAWSDDGVVMGLRHRE
KPLWGVQFHPESIGSDFGREIMANFRDLALAHHRARRHDSPYELHVRRVD
VLPDAEEVRRGCLPGEGTTFWLDSSSVLEGASRFSFLGDDRGPLAEYLTY
RVADGVVSVRGSDGTTTRTRRPFFNYLEEQLERRRVPVAPELPFEFNLGY
VGYLGYELKAETTGDPAHRSPHPDAAFLFADRAIALDHQEGCCYLLALDR
RGHDDGARAWLRETAETLTGLAVRAPGFGPLARARHDKDAYLKRIDECLK
EIRNGESYEICLTNMVTAPTEATALPLYSALRAISPVPYGALLEFPELSV
LSASPERFLTIGADGGVESKPIKGTRPRGGTAEEDERLRADLAGREKDRA
ENLMIVDLVRNDLNSVCAIGSVHVPRLFEVETYAPVHQLVSTIRGRLRPG
TSTAACVRAAFPGGSMTGAPKKRTMEIIDRLEEGPRGVYSGALGWFALSG
AADLSIVIRTIVLADGQAEFGVGGAIVSLSDQEEEFTETVVKARAMVTAL
D

3D structure

• PDB: 8hx6 Structural basis for the allosteric pathway of 4-amino-4-deoxychorismate synthase.
• Chain: B
• Resolution: 2.14 Å

Enzymatic activity

• Enzyme Commision number: 2.6.1.85: aminodeoxychorismate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TRP	B	L233 D234 S235 F245 P465 Y466 G467 L620 G621	L222 D223 S224 F234 P438 Y439 G440 L593 G594

Gene Ontology

Molecular Function

• GO:0016740 transferase activity
• GO:0046820 4-amino-4-deoxychorismate synthase activity

Biological Process

• GO:0006541 glutamine metabolic process
• GO:0008153 para-aminobenzoic acid biosynthetic process
• GO:0009058 biosynthetic process
• GO:0009396 folic acid-containing compound biosynthetic process
• GO:0017000 antibiotic biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8hx6, PDBe:8hx6, PDBj:8hx6
• PDBsum: 8hx6
• PubMed: 37712435
• UniProt: F2RB79|ADCS_STRVP Aminodeoxychorismate synthase (Gene Name=cmlB)