Structure of PDB 8hut Chain B

Receptor sequence
>8hutB (length=290) Species: 1335626 (Middle East respiratory syndrome-related coronavirus) [Search protein sequence]
GLVKMSHPSGDVEACMVQVTCGSMTLNGLWLDNTVWCPRHVMCPLSDPNY
DALLISMTNHSFSVQKHLRVVGHAMQGTLLKLTVDVANPSTPAYTFTTVK
PGAAFSVLACYNGRPTGTFTVVMRPNYTIKGSFLCGSAGSVGYTKEGSVI
NFCYMHQMELANGTHTGSAFDGTMYGAFMDKQVHQVQLTDKYCSVNVVAW
LYAAILNGCAWFVKPNRTSVVSFNEWALANQFTEFVGTQSVDMLAVKTGV
AIEQLLYAIQQLYTGFQGKQILGSTMLEDEFTPEDVNMQI
3D structure
PDB8hut Crystal structure of MERS main protease in complex with S217622
ChainB
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7YY B M25 T26 H41 F143 L144 C145 G146 S147 A148 H166 Q167 M168 E169 D190 K191 M24 T25 H40 F133 L134 C135 G136 S137 A138 H156 Q157 M158 E159 D180 K181
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:8hut, PDBe:8hut, PDBj:8hut
PDBsum8hut
PubMed37421945
UniProtK9N7C7|R1AB_MERS1 Replicase polyprotein 1ab (Gene Name=rep)

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