Structure of PDB 8hr0 Chain B

Receptor sequence
>8hr0B (length=729) Species: 9606 (Homo sapiens) [Search protein sequence]
EGLRVVNLLQERNMLPSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQ
TQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVSFL
DQRRWKCNLCYRVNDVPEEEPHRRPEVQNATIEFMAPSEYMLRPPQPPVY
LFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFY
GLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKELVQDLLKTLPQMF
TKTLETQSALGPALQAAFKLMSPTGGRMSVFQTQLPTLGVGALKPREEPN
HRSSAKMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYS
AGSVYYYPSYHHQHNPVQVQKLQKELQRYLTRKIGFEAVMRIRCTKGLSI
HTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLY
TSSKGERRIRVHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSMTAS
LSDARDALVNAVIDSLSAYRSSVPGLMVPFSLRLFPLFVLALLKQKSFQT
GTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRT
IPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNY
ASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMKAN
FLQNMIEDRTESALSYYEFLLHIQQQVNK
3D structure
PDB8hr0 Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations
ChainB
Resolution3.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R430 Y437 R750 R752 A806 L808 R85 Y92 R391 R393 A447 L449
BS02 ZN B C431 C452 C455 C86 C107 C110
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Cellular Component
GO:0030127 COPII vesicle coat

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hr0, PDBe:8hr0, PDBj:8hr0
PDBsum8hr0
PubMed
UniProtO95486|SC24A_HUMAN Protein transport protein Sec24A (Gene Name=SEC24A)

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