Structure of PDB 8hoi Chain B

Receptor sequence
>8hoiB (length=137) Species: 9606 (Homo sapiens) [Search protein sequence]
DNREIVMKYIHYKLSQRGYEWDAEVVHLTLRQAGDYFSRRYRRDFAEMSS
QLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMS
PLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGP
3D structure
PDB8hoi Crystal structure of Bcl-2 D103Y in complex with sonrotoclax
ChainB
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 98I B Y103 L201 Y202 Y36 L134 Y135
BS02 98I B A100 Y103 F104 Y108 D111 F112 M115 W144 G145 R146 V148 A149 Y202 A33 Y36 F37 Y41 D44 F45 M48 W77 G78 R79 V81 A82 Y135
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:8hoi, PDBe:8hoi, PDBj:8hoi
PDBsum8hoi
PubMed38211332
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2)

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