Structure of PDB 8hni Chain B

Receptor sequence

>8hniB (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]

REKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGF
GFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKL
FVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHD
PVDKIVLQKYHTINGHNAEVRKALSRQEM

3D structure

PDB

8hni Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition.

Chain

Resolution

2.644 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	B	K17 E18 T48 Y174 N181	K3 E4 T34 Y160 N167
BS02	dna	B	Q19 K22 F24 G27 L28 S29 F30 D49 M53 R62 G63 F64 F66 R89 E92 K94 A96 V97 R99 H108	Q5 K8 F10 G13 L14 S15 F16 D35 M39 R48 G49 F50 F52 R75 E78 K80 A82 V83 R85 H94
BS03	dna	B	K113 F115 G118 R153 G154 F155 F157 R185 A187 L188 R190 M193	K99 F101 G104 R139 G140 F141 F143 R171 A173 L174 R176 M179
BS04	dna	B	R15 K46	R1 K32

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

View graph for
Molecular Function

External links

PDB	RCSB:8hni, PDBe:8hni, PDBj:8hni
PDBsum	8hni
PubMed	36528084
UniProt	P22626\|ROA2_HUMAN Heterogeneous nuclear ribonucleoproteins A2/B1 (Gene Name=HNRNPA2B1)

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