Structure of PDB 8hmy Chain B

Receptor sequence
>8hmyB (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
MLVVEVANGRSLVWGAEAVQALRERLGVGGRTVGALPRGPRQNSRLGLPL
LLMPEEARLLAEIGAVTLVSAPRPDSRHHSLALTSFKRQQEESFQEQSAL
AAEARETRRQELLEKITEGQAAKKQKLEQASGASPRSALLVQLATARPRP
VKARPLDWRVQSKDWPHAGRPAHELRYSIYRDLWERGFFLSAAGKFGGDF
LVYPGDPLRFAAHYIAQCWAPEDTIPLQDLVAAGRLGTSVRKTLLLCSPQ
PDGKVVYTSLQWAS
3D structure
PDB8hmy Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease.
ChainB
Resolution2.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.16: tRNA-intron lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B R31 R41 R105 R108 L112 K115 I116 K239 Y247 A255 R285 K286 R31 R41 R105 R108 L112 K115 I116 K195 Y203 A211 R241 K242
Gene Ontology
Molecular Function
GO:0000213 tRNA-intron endonuclease activity
GO:0003676 nucleic acid binding
GO:0016829 lyase activity
Biological Process
GO:0000379 tRNA-type intron splice site recognition and cleavage
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006397 mRNA processing
GO:0008033 tRNA processing
Cellular Component
GO:0000214 tRNA-intron endonuclease complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus

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Cellular Component
External links
PDB RCSB:8hmy, PDBe:8hmy, PDBj:8hmy
PDBsum8hmy
PubMed37028420
UniProtQ9BSV6|SEN34_HUMAN tRNA-splicing endonuclease subunit Sen34 (Gene Name=TSEN34)

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