Structure of PDB 8hkw Chain B

Receptor sequence

>8hkwB (length=415) Species: 9606 (Homo sapiens) [Search protein sequence]

TSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILV
HCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPH
QNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNV
TWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLT
DAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQ
VVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLV
PMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLL
TVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHEN
EDIYKLAYEIIDQFF

3D structure

PDB

8hkw Crystallographic data of an importin-alpha 3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal.

Chain

Resolution

1.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	S100 D102 R103 F133 W137 N141 S144 G145 T146 T150 Q176 W179 N183 D187 N219 W222 N226 R229 W264 Y268	S30 D32 R33 F63 W67 N71 S74 G75 T76 T80 Q106 W109 N113 D117 N149 W152 N156 R159 W194 Y198
BS02	peptide	B	D271 R306 V312 T313 W348 N352 E387 W390	D201 R236 V242 T243 W278 N282 E317 W320

External links

PDB	RCSB:8hkw, PDBe:8hkw, PDBj:8hkw
PDBsum	8hkw
PubMed	36875212
UniProt	O00629\|IMA3_HUMAN Importin subunit alpha-3 (Gene Name=KPNA4)

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