Structure of PDB 8heo Chain B

Receptor sequence
>8heoB (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]
SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLD
AVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLV
LEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRS
IHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
3D structure
PDB8heo Crystal structure of SIAH1 SBD bound to Axin2 peptide
ChainB
Resolution2.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B T156 L158 V164 F165 L166 T168 A175 D177 W178 T64 L66 V72 F73 L74 T76 A83 D85 W86
BS02 ZN B C98 H117 C121 C6 H25 C29
BS03 ZN B C128 C135 H147 H152 C36 C43 H55 H60
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organism development
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:8heo, PDBe:8heo, PDBj:8heo
PDBsum8heo
PubMed
UniProtQ8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 (Gene Name=SIAH1)

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