Structure of PDB 8h9s Chain B

Receptor sequence
>8h9sB (length=477) Species: 9606 (Homo sapiens) [Search protein sequence]
DLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGV
VVFGNDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGS
KTRRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQT
GKTSIAIDTIINQKRFNDGSDEKKKLYCIYVAIGQKRSTVAQLVKRLTDA
DAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSK
QAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDAFGGGSLTA
LPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSR
VGSAAQTRAMKQVAGTMKLELAQYREVADAATQQLLSRGVRLTELLKQGQ
YSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVVSQHQALLGT
IRADGKISEQSDAKLKEIVTNFLAGFE
3D structure
PDB8h9s Structure of the human ATP synthase.
ChainB
Resolution2.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B Q172 G174 K175 T176 S177 F357 R362 Q432 Q149 G151 K152 T153 S154 F334 R339 Q400
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0032559 adenyl ribonucleotide binding
GO:0042288 MHC class I protein binding
GO:0043531 ADP binding
GO:0043532 angiostatin binding
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
Biological Process
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006629 lipid metabolic process
GO:0006754 ATP biosynthetic process
GO:0014850 response to muscle activity
GO:0015986 proton motive force-driven ATP synthesis
GO:0042776 proton motive force-driven mitochondrial ATP synthesis
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045471 response to ethanol
GO:0046034 ATP metabolic process
GO:0071549 cellular response to dexamethasone stimulus
GO:0071732 cellular response to nitric oxide
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0008180 COP9 signalosome
GO:0009986 cell surface
GO:0016020 membrane
GO:0016469 proton-transporting two-sector ATPase complex
GO:0031090 organelle membrane
GO:0045121 membrane raft
GO:0045259 proton-transporting ATP synthase complex
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)
GO:0045267 proton-transporting ATP synthase, catalytic core
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h9s, PDBe:8h9s, PDBj:8h9s
PDBsum8h9s
PubMed37244256
UniProtP25705|ATPA_HUMAN ATP synthase subunit alpha, mitochondrial (Gene Name=ATP5F1A)

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