Structure of PDB 8h7b Chain B

Receptor sequence
>8h7bB (length=144) Species: 9606 (Homo sapiens) [Search protein sequence]
SDELYRQSLEIISRYLREQATGAKDGATSRKALETLRRVGDGVQRNHETA
FQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKH
LKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
3D structure
PDB8h7b 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases.
ChainB
Resolution1.46408 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QHR B R187 E288 R17 E111
BS02 QHR B A227 F228 M231 K234 M250 V253 R263 T266 L267 F270 G271 A50 F51 M54 K57 M73 V76 R86 T89 L90 F93 G94
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:8h7b, PDBe:8h7b, PDBj:8h7b
PDBsum8h7b
PubMed36774655
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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