Structure of PDB 8h65 Chain B

Receptor sequence
>8h65B (length=163) Species: 9606 (Homo sapiens) [Search protein sequence]
GIIEFHVIGNSLANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHK
TLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLK
EYHIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGAT
LMECELNPRIPYT
3D structure
PDB8h65 Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BCO B V577 C579 V581 Q586 V587 G589 G591 T592 T612 Y613 A618 G620 Y621 F622 K624 V78 C80 V82 Q87 V88 G90 G92 T93 T113 Y114 A119 G121 Y122 F123 K125
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:8h65, PDBe:8h65, PDBj:8h65
PDBsum8h65
PubMed37040526
UniProtQ92830|KAT2A_HUMAN Histone acetyltransferase KAT2A (Gene Name=KAT2A)

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