Structure of PDB 8h53 Chain B

Receptor sequence
>8h53B (length=429) Species: 9606 (Homo sapiens) [Search protein sequence]
EPKCVKIGALEGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVL
ADELCQCYNGVLLSTESSVAVYGMLNLTPKGKQAPGGHELSCDFWELIGL
APAGSDVDVQLNNRHMMIRGENMSKILKARSMVTRCFRDHFFDRGYYEVT
PPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLPALGDVFCIAQ
SYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLNRLEDLVCDVVDRILKSP
AGSIVHELNPNFQPPKRPFKRMNYSDAIVWLKEHDVKKEDGTFYEFGEDI
PEAPERLMTDTINEPILLCRFPVEIKSFYMQRCPEDSRLTESVDVLMPNV
GEIVGGSMRIFDSEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLG
LERFLTWILNRYHIRDVCLYPRFVQRCTP
3D structure
PDB8h53 Human asparaginyl-tRNA synthetase in complex with asparagine-AMP
ChainB
Resolution2.16 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.1.1.22: asparagine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4AD B E279 S299 Q301 R322 E324 H331 L332 Y335 H337 E339 E471 I472 V473 R478 Y516 G517 G519 R522 E160 S180 Q182 R203 E205 H212 L213 Y216 H218 E220 E352 I353 V354 R359 Y397 G398 G400 R403
BS02 2PN B R330 H331 E471 R522 R211 H212 E352 R403
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004816 asparagine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006421 asparaginyl-tRNA aminoacylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8h53, PDBe:8h53, PDBj:8h53
PDBsum8h53
PubMed38297033
UniProtO43776|SYNC_HUMAN Asparagine--tRNA ligase, cytoplasmic (Gene Name=NARS1)

[Back to BioLiP]