Structure of PDB 8h0z Chain B

Receptor sequence
>8h0zB (length=1045) Species: 2901879 (Severe acute respiratory syndrome coronavirus) [Search protein sequence]
TQHTSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSNVTGFHNPVIPFKDGI
YFAATEKSNVVRGWVFGSTMNNKSQSVIIINNSTNVVIRACNFELCDNPF
FTMIFDNAFNCTFEYISDAFKHLREFVFKNKDGFLYVYKGYQPIDVVRDL
PSGFNTLKPIFKLPLGINITNFRAILTAAAAYFVGYLKPTTFMLKYDENG
TITDAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVRFPNIT
NLCPFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVC
ATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCV
LAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPP
ALNCYWPLNDYGFYTTTGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLI
KNQCVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDPKTSEI
LDISPCSFGGVSVITPGTNASSEVAVLYQDVNCTDVSTAIHADQLTPAWR
IYSTGNNVFQTQAGCLIGAEHVDTSYECDIPIGAGICASYHTQKSIVAYT
MSLGADSSIAYSNNTIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDS
TECANLLLQYGSFCTQLNRALSGIAAEQDRNTREVFAQVKQMYKTPTLKY
FGGFNFSQILPDPLKPTKRSFIEDLLFNKVTLADAGFMKQYGECLGDINA
RDLICAQKFNGLTVLPPLLTDDMIAAYTAALVSGTATAGWTFGAGAALQI
PFAMQMAYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTALG
KLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLCKVEAEVQIDRL
ITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKG
YHLMSFPQAAPHGVVFLHVTYVPSQERNFTTAPAICHEGKAYFPREGVFV
FNGTSWFITQRNFFSPQIITTDNTFVSGNCDVVIGIINNTVYDPL
3D structure
PDB8h0z Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
ChainB
Resolution2.99 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BLA B G100 W101 N118 F168 R183 F185 G63 W64 N81 F120 R124 F126
BS02 EIC B F325 I345 Y352 F361 F364 L374 F255 I275 Y282 F291 F294 L304
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039587 suppression by virus of host tetherin activity
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046598 positive regulation of viral entry into host cell
GO:0046718 symbiont entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0052170 symbiont-mediated suppression of host innate immune response
GO:0061025 membrane fusion
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0055036 virion membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8h0z, PDBe:8h0z, PDBj:8h0z
PDBsum8h0z
PubMed37402591
UniProtP59594|SPIKE_SARS Spike glycoprotein (Gene Name=S)

[Back to BioLiP]