Structure of PDB 8h0w Chain B

Receptor sequence
>8h0wB (length=1161) Species: 460519 (Komagataella phaffii) [Search protein sequence]
DDTITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLIL
DQPAQHTNEKDNINKRYEIRFGKIYLSRPTMTEADGTTHAMFPQEARLRN
LTYSSPVYLDMEKSMFTSIDGNKVHIGKVPIMLRSKFCSLRTLDEVDLYK
MKECPYDMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIR
SALEKGSRLISTMQIKLYGREDKGTGRTIKATLPYVKQDIPIVIVFRALG
VVPDGEILQHICYDENDWQMLEMLKPCIEEGFVIQDKEVALDFIGRRGSA
ALGIRREKRIQYAKDILQKELLPHITQEEGFETRKTFFLGYMVNRLLLCA
LERKDQDDRDHFGKKRLDLAGPLLANLFRILFRKLTREIYRYMQRCIETD
RDFNLNLAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYTYS
STLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNL
SLLSGISIGSPSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGI
HRDPSMLVSTMRDLRRSGAISPEVSIIRDIREREFKIFTDVGRVYRPLFI
VEDDESKDNKGELRITKEHIRKIQQGYDDDVYGWSSLVTSGVIEYVDGEE
EETIMIAMTPEDLQTRSLNDTAKRIKPEMSTSSHHTFTHCEIHPSMILGV
AASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQK
PLAKTQAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLF
RSLFFRSYMDQEKRFGISIVEEFEKPTRATTLRLKHGTYEKLDEDGLIAP
GVRVSGDDIIIGKTTPIPPYHTKRDASTPLRSTENGIVDQVLLTTNQEGL
KFVKVRMRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSAEGIVPDLI
INPHAIPSRMTVAHLIECLLSKVGSIRGYEGDATPFTDLTVDAVSNLLRD
NGYQSRGFEVMYNGHTGKKLMAQVFFGPTYYQRLRHMVDDKIHARARGPV
QVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAGFLKERLMEASDAFRVH
VCGICGLMSVIANLKKNQFECRSCKNKTNIYQLHIPYAAKLLFQELMAMN
IAPRLYTERSG
3D structure
PDB8h0w Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1.
ChainB
Resolution4.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B G471 Q474 Q776 R884 L885 H887 K979 K987 H1097 R1124 G439 Q442 Q725 R833 L834 H836 K918 K926 H1036 R1063
BS02 dna B A455 T791 M792 R857 R1122 R1129 A423 T740 M741 R806 R1061 R1068
BS03 ZN B C1163 C1166 C1182 C1185 C1102 C1105 C1121 C1124
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h0w, PDBe:8h0w, PDBj:8h0w
PDBsum8h0w
PubMed36435862
UniProtC4QZQ7

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