Structure of PDB 8h0i Chain B

Receptor sequence
>8h0iB (length=345) Species: 9606 (Homo sapiens) [Search protein sequence]
GPGHMDPDTFSYNFNNRPILSRRNTVWLCYEVERLDNGTWVKMDQHRGQV
YSELKYHPEMRFLSLVSKWKLHRDQEYEVTWYISWSPCTKCARDMATFLQ
ENTHVTLTIFVARLYYFWDPDYQEALRSLAQAGATIKIMNYDEFQHCWSK
FVYSQGAPFQPWDGLDEYSQALSGMLGEILRHSMDPPTFTFNFNNERHET
YLCYEVERMHNDTWVKLNQRRGFLANQRHAELCFLDVIPFWKLDLDQDYR
VTCFTSWSPCFSCAQEMAKFISKNKHVSLCIKTARIYQEGLRTLAEAGAK
ISIMTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAIL
3D structure
PDB8h0i Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B H0 Y8 N9 R13 I15 L16 S17 R18 N20 T21 S48 E49 H53 W81 Y111 Y112 W114 K253 H4 Y12 N13 R17 I19 L20 S21 R22 N24 T25 S52 E53 H57 W85 Y115 Y116 W118 K242
BS02 ZN B H53 C84 C87 H57 C88 C91
BS03 ZN B H240 C271 C274 H229 C260 C263
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:8h0i, PDBe:8h0i, PDBj:8h0i
PDBsum8h0i
PubMed37419875
UniProtQ9HC16|ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (Gene Name=APOBEC3G)

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