Structure of PDB 8gzr Chain B

Receptor sequence

>8gzrB (length=443) Species: 12637 (Dengue virus)

PELEEEMFKKRNLTIMDLHPGSGKTRKYLPAIVREAIKRRLRTLILAPTR
VVAAEMEEALKGLPIRYQTTATKSEHTGKEIVDLMCHATFTMRLLSPVRV
PNYNLIIMDEAHFTDPASIAARGYISTRVGMGEAAAIFMTATPPGTADAF
PQSNAPIQDEERDIPERSWNSGNDWITDFAGKTVWFVPSIKAGNDIANCL
RKNGKKVIQLSRKTFDTEYQKTKLNDWDFVVTTDISEMGANFKADRVIDP
RRCLKPVILTDGPERVILAGPMPVTVASAAQRRGRVGRNPQKENDQYIFT
GQPLNNDEDHAHWTEAKMLLDNINTPEGIIPALFEPEREKSAAIDGEYRL
KGESRKTFVELMRRGDLPVWLAHKVASEGIKYTDRKWCFDGERNNQILEE
NMDVEIWTKEGEKKKLRPRWLDARTYSDPLALKEFKDFAAGRK

3D structure

• PDB: 8gzr Structures of dengue virus RNA replicase complexes.
• Chain: B
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.91: flavivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	R226 T245 T246 A264 T265 R269 V274 P364 S365 I366 R388 T409 D410 I411 L430 P432 L444 R539 D542	R50 T69 T70 A88 T89 R93 V98 P188 S189 I190 R212 T233 D234 I235 L254 P256 L268 R363 D366
BS02	CDP	B	G197 G199 K200 T201 R202 N417 K419 R464	G21 G23 K24 T25 R26 N241 K243 R288

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003724 RNA helicase activity
• GO:0004386 helicase activity
• GO:0005524 ATP binding

External links

• PDB: RCSB:8gzr, PDBe:8gzr, PDBj:8gzr
• PDBsum: 8gzr
• PubMed: 37478848
• UniProt: Q5I3C1