Structure of PDB 8gzc Chain B

Receptor sequence
>8gzcB (length=437) Species: 9606 (Homo sapiens) [Search protein sequence]
YCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGE
SVSLGTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPA
GFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPES
GEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDG
VDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEIL
IGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWFK
KMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIK
ESGGSGSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLM
DGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQ
3D structure
PDB8gzc Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1163 C1164 H1255 C1258 C2 C3 H87 C90
BS02 ZN B C1247 C1250 C1272 C1275 C79 C82 C104 C107
BS03 ZN B C1177 C1183 C1201 C1204 C16 C22 C40 C43
BS04 KQO B L1398 D1399 S1400 Y1414 P1440 H1451 Q1455 I1457 P1458 L1463 W1466 L230 D231 S232 Y246 P272 H283 Q287 I289 P290 L295 W298
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8gzc, PDBe:8gzc, PDBj:8gzc
PDBsum8gzc
PubMed36572866
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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