Structure of PDB 8gyw Chain B

Receptor sequence
>8gywB (length=380) Species: 9606 (Homo sapiens) [Search protein sequence]
TGCVLNKLFQLPTPPLSRHQLKRLEEHRYQSAGRSLLEPLMQGYWEWLVR
RVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYIACACGLF
IYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGT
NPDWMFFCCFAGTFMFYCAHWQTYVSGTLRFGIIDVTEVQIFIIIMHLLA
VIGGPPFWQSMIPVLNIQMKIFPALCTVAGTIFSCTNYFRVIFTGGVGKN
GSTIAGTSVLSPFLHIGSVITLAAMIYKKSAVQLFEKHPCLYILTFGFVS
AKITNKLVVAHMTKSEMHLHDTAFIGPALLFLDQYFNSFIDEYIVLWIAL
VFSFFDLIRYCVSVCNQIASHLHIHVFRIK
3D structure
PDB8gyw Structural basis for catalysis of human choline/ethanolamine phosphotransferase 1.
ChainB
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.8.1: ethanolaminephosphotransferase.
2.7.8.2: diacylglycerol cholinephosphotransferase.
2.7.8.22: 1-alkenyl-2-acylglycerol choline phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D133 D136 D106 D109
BS02 MG B D133 D154 D158 D106 D127 D131
BS03 CDC B Y56 E65 W72 D133 D136 G137 A140 R141 G150 E151 D154 Y29 E38 W45 D106 D109 G110 A113 R114 G123 E124 D127
Gene Ontology
Molecular Function
GO:0004142 diacylglycerol cholinephosphotransferase activity
GO:0004307 ethanolaminephosphotransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
GO:0046872 metal ion binding
GO:0047359 1-alkenyl-2-acylglycerol choline phosphotransferase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006657 CDP-choline pathway
GO:0008654 phospholipid biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0031965 nuclear membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gyw, PDBe:8gyw, PDBj:8gyw
PDBsum8gyw
PubMed37137909
UniProtQ9Y6K0|CEPT1_HUMAN Choline/ethanolaminephosphotransferase 1 (Gene Name=CEPT1)

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