Structure of PDB 8gyd Chain B

Receptor sequence
>8gydB (length=215) Species: 6182 (Schistosoma japonicum) [Search protein sequence]
SPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLE
FPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLD
IRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHP
DFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAW
PLQGWQATFGGGDHP
3D structure
PDB8gyd Discovery, SAR Study of GST Inhibitors from a Novel Quinazolin-4(1 H )-one Focused DNA-Encoded Library.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.18: glutathione transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0IH B W8 G12 L13 R35 R103 S107 R108 Y111 Q204 G205 W206 Q207 W7 G11 L12 R34 R102 S106 R107 Y110 Q203 G204 W205 Q206
BS02 0IH B H31 K40 K44 E47 L48 Y57 H30 K39 K43 E46 L47 Y56
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0016740 transferase activity
Biological Process
GO:0006749 glutathione metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8gyd, PDBe:8gyd, PDBj:8gyd
PDBsum8gyd
PubMed37552553
UniProtP08515|GST26_SCHJA Glutathione S-transferase class-mu 26 kDa isozyme

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