Structure of PDB 8gv3 Chain B

Receptor sequence
>8gv3B (length=373) Species: 9606 (Homo sapiens) [Search protein sequence]
NEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTL
SGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKF
CLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVV
ADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEPGSVCAVFGLGG
VGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQE
VLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIA
TRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSF
DEINKAFELMHSGKSIRTVVKIE
3D structure
PDB8gv3 The cryo-EM structure of GSNOR with NYY001
ChainB
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.-
1.1.1.1: alcohol dehydrogenase.
1.1.1.284: S-(hydroxymethyl)glutathione dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C102 C110 C101 C109
BS02 ZN B C44 H66 C173 C43 H65 C172
BS03 NAD B C173 V202 D222 I223 C267 I268 V291 G292 C172 V201 D221 I222 C266 I267 V290 G291
BS04 WKZ B T46 Y92 I93 P94 L109 C110 M140 C173 T45 Y91 I92 P93 L108 C109 M139 C172
Gene Ontology
Molecular Function
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0005504 fatty acid binding
GO:0008270 zinc ion binding
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0018467 formaldehyde dehydrogenase (NAD+) activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
GO:0080007 S-nitrosoglutathione reductase (NADH) activity
GO:0106321 S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity
GO:0106322 S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0003016 respiratory system process
GO:0006629 lipid metabolic process
GO:0010430 fatty acid omega-oxidation
GO:0032496 response to lipopolysaccharide
GO:0044281 small molecule metabolic process
GO:0045777 positive regulation of blood pressure
GO:0046294 formaldehyde catabolic process
GO:0051409 response to nitrosative stress
GO:0051775 response to redox state
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gv3, PDBe:8gv3, PDBj:8gv3
PDBsum8gv3
PubMed
UniProtP11766|ADHX_HUMAN Alcohol dehydrogenase class-3 (Gene Name=ADH5)

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