Structure of PDB 8gru Chain B

Receptor sequence
>8gruB (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
SFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL
EQVLSSMKENKVAIIGKIHLASYDMRLRRKLDLFANVVHVKSLPGYMTRH
NNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYA
TKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCM
QLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFET
GARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKV
GKVRTSDMGGYATCHDFTEEICRRVKDLDEN
3D structure
PDB8gru Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction.
ChainB
Resolution2.847 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD B N186 I215 N218 N165 I194 N197
BS02 NAD B A254 G255 H275 P276 F277 A278 N287 A233 G234 H254 P255 F256 A257 N266
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8gru, PDBe:8gru, PDBj:8gru
PDBsum8gru
PubMed36375638
UniProtO43837|IDH3B_HUMAN Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Gene Name=IDH3B)

[Back to BioLiP]