Structure of PDB 8grd Chain B

Receptor sequence
>8grdB (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]
FPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQMASEEKLEQ
VLSSMKENKVAIIGKIHLASYDMRLRRKLDLFANVVHVKSLPGYMTRHNN
LDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATK
KGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQL
VQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGA
RHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGK
VRTSDMGGYATCHDFTEEICRRVKDLD
3D structure
PDB8grd Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction.
ChainB
Resolution2.699 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B A254 G255 H275 F277 N287 A231 G232 H252 F254 N264
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:8grd, PDBe:8grd, PDBj:8grd
PDBsum8grd
PubMed36375638
UniProtO43837|IDH3B_HUMAN Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Gene Name=IDH3B)

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