Structure of PDB 8gmn Chain B

Receptor sequence
>8gmnB (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
IENGYTCEEPYYYMEGPKCVPVCGVPREPFEEKIIGGSDADIKNFPWQVF
FDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLT
PEHVFIHPGWKLLAVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTS
SDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEEAY
VFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCG
TYGLYTRVKNYVDWIMKTMQENS
3D structure
PDB8gmn Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.42: complement subcomponent C1s.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZWK B H475 D626 S627 C628 K629 S632 S654 W655 G656 C659 H71 D216 S217 C218 K219 S222 S244 W245 G246 C249
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8gmn, PDBe:8gmn, PDBj:8gmn
PDBsum8gmn
PubMed37120845
UniProtP09871|C1S_HUMAN Complement C1s subcomponent (Gene Name=C1S)

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