Structure of PDB 8gh7 Chain B

Receptor sequence
>8gh7B (length=92) Species: 9606 (Homo sapiens) [Search protein sequence]
TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHC
GGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLT
3D structure
PDB8gh7 Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist.
ChainB
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B G306 L307 T308 D309 W310 K311 E314 Q319 W323 Y324 G53 L54 T55 D56 W57 K58 E61 Q66 W70 Y71
BS02 ZN B L292 K299 G306 L307 L39 K46 G53 L54
BS03 ZN B C300 C303 H320 C327 C47 C50 H67 C74
External links
PDB RCSB:8gh7, PDBe:8gh7, PDBj:8gh7
PDBsum8gh7
PubMed37262387
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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