Structure of PDB 8ges Chain B

Receptor sequence
>8gesB (length=643) Species: 301301 (Roseburia hominis) [Search protein sequence]
MREVINFNTWAFTKEATEVPKEMPEKWYWVTLPHSWNEIDGQDGGNDYYR
GTCYYAKQLKKSELPEADCYYLELRGANASADVYVNGKAVAHHDGGYSTW
RVDITKELTEEENLIVIAVENGVNDRVYPQNADFTFYGGLYRDVNIIAVN
KSHFDLDYYGGPGIKVTPEIKGADASVEVEVFLTNAAADQKLVYTVKDAE
GKEVAKTETAAGETKAVLSIPAVHLWNGKKDPYLYTAEVALVSGEEAVDA
VSTRFGCRTFEIDPERGFILNGEEYPLRGVSRHQDRWGIGNALLPEHHRE
DIDLICELGATTIRLAHYQHDQYFYDLCDERGLVIWAEIPYISSHMPNGR
ENTISQMKELVVQNYNHPSIVVWGLSNEITMAGSSDEDLLENHRILNDMV
HEMDHTRLTTIAVVSMCDIHDPYIQIPDVISYNHYFGWYGGDVSMNGPWM
DNFHKEFPNIPLGMSEYGCEALNWHTSDPKQGDYTEEYQAYYHEEMIKQL
FTRKYIWATHVWNMFDFGADARNEGGENGQNHKGLVTFDRKYKKDSFYAY
KAWLSDEPFVHLCGKRYVDRVEDTTKVTVYSNLPEVELFVNGKSAGKLQA
EDHFFHFEVPNVGESTLVAVAGEYKDESHIRKVDTFNEEYSLK
3D structure
PDB8ges Diverse Human Therapeutics Impact Hormone and Neurotransmitter Homeostasis by Inhibiting Gut Microbial Enzymes
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN B D155 Y158 K165 F183 K359 V363 Y366 D155 Y158 K165 F182 K358 V362 Y365
BS02 I9G B D133 H318 E379 Y436 Y440 E467 W513 F518 R523 N532 K534 D133 H317 E378 Y435 Y439 E466 W512 F517 R522 N531 K533
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004565 beta-galactosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ges, PDBe:8ges, PDBj:8ges
PDBsum8ges
PubMed38754417
UniProtA0A395V8I7

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