Structure of PDB 8gbq Chain B

Receptor sequence
>8gbqB (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
SFDCAVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEG
VPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQKYIDKY
3D structure
PDB8gbq Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation.
ChainB
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C37 C40 C57 C60 C4 C7 C24 C27
BS02 ZN B C52 H54 C72 C75 C19 H21 C39 C42
BS03 ZN B C100 C103 H115 C119 C67 C70 H82 C86
External links
PDB RCSB:8gbq, PDBe:8gbq, PDBj:8gbq
PDBsum8gbq
PubMed37541247
UniProtQ96EQ8|RN125_HUMAN E3 ubiquitin-protein ligase RNF125 (Gene Name=RNF125)

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