Structure of PDB 8gb1 Chain B

Receptor sequence
>8gb1B (length=439) Species: 9606 (Homo sapiens) [Search protein sequence]
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPF
SHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEE
DICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKW
DYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMF
HTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAI
DDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPT
GQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDHVSFPEK
FAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQD
3D structure
PDB8gb1 Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding.
ChainB
Resolution2.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YWI B K116 I118 D137 R145 K3 I5 D24 R32
BS02 YWI B Y155 V156 V378 R451 N452 L453 F454 K455 V557 Y42 V43 V265 R338 N339 L340 F341 K342 V413
BS03 FE B H167 H206 D207 D311 H54 H93 D94 D198
External links
PDB RCSB:8gb1, PDBe:8gb1, PDBj:8gb1
PDBsum8gb1
PubMed37233733
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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