Structure of PDB 8ga2 Chain B

Receptor sequence
>8ga2B (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
KKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKN
PMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKL
AEVFEQEIDPVMQSLG
3D structure
PDB8ga2 Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition
ChainB
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YVK B L1109 P1110 Y1167 N1168 R1173 V1174 F1177 L28 P29 Y86 N87 R92 V93 F96
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8ga2, PDBe:8ga2, PDBj:8ga2
PDBsum8ga2
PubMed38664416
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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