Structure of PDB 8g8o Chain B

Receptor sequence
>8g8oB (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHL
RDFEREIEILKSLQHDNIVKYKGVCYSRRNLKLIMEYLPYGSLRDYLQKH
KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGD
FGLTKVLPQDKEYYKVKESPIFWYAPESLTESKFSVASDVWSFGVVLYEL
FTYIEKSKSPPAEFMRMIGGQSIVTHLIELLKNNGRLPRPDGCPDEIYMI
MTECWNNNVNQRPSFRDLALRVDQIRDNM
3D structure
PDB8g8o Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YT0 B L855 A880 M929 Y931 L932 G935 R980 N981 L983 G993 D994 L13 A38 M85 Y87 L88 G91 R136 N137 L139 G149 D150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8g8o, PDBe:8g8o, PDBj:8g8o
PDBsum8g8o
PubMed37314941
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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