Structure of PDB 8g0h Chain B

Receptor sequence
>8g0hB (length=473) Species: 9606 (Homo sapiens) [Search protein sequence]
AAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKE
NRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKN
FTKYPKKFYPLEIDYGGTKSKLPKPVQDLIKMIFDVESMKKAMYEIDLQK
MPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFG
MKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGDSSKDPIDVNYEKL
KTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQR
YKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYF
ADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHS
VKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQV
NLKYLLKLKFNFKTSLWLEHHHH
3D structure
PDB8g0h Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks
ChainB
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B Y570 R587 W589 K600 K621 F638 Y40 R57 W59 K70 K91 F108
BS02 YH0 B Y710 L713 Q717 A762 H862 G863 P885 G888 Y889 Y896 F897 K903 Y907 E988 Y165 L168 Q172 A217 H315 G316 P338 G341 Y342 Y349 F350 K356 Y360 E441
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8g0h, PDBe:8g0h, PDBj:8g0h
PDBsum8g0h
PubMed38372302
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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