Structure of PDB 8fz1 Chain B

Receptor sequence
>8fz1B (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
TKSKLPKPVQDLIKMIFDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKN
THATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFA
GILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLIL
LGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVP
LGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNF
3D structure
PDB8fz1 Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC B Y992 D993 Y222 D223
BS02 FRU B P942 K943 G944 K945 H946 P172 K173 G174 K175 H176
BS03 YVB B H862 G863 R865 N868 Y889 Y896 F897 S904 Y907 H92 G93 R95 N98 Y119 Y126 F127 S134 Y137
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8fz1, PDBe:8fz1, PDBj:8fz1
PDBsum8fz1
PubMed38372302
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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