Structure of PDB 8fyu Chain B

Receptor sequence
>8fyuB (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]
KSPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYL
KMQQHEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAY
SLAKEQRLNFGDDIPSALRIAKKKRWNS
3D structure
PDB8fyu Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP.
ChainB
Resolution1.84839 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K31 N35 F38 Y50 N66 L69 K73 K96 F99 N131 F132 G133 D135 K9 N13 F16 Y28 N44 L47 K51 K74 F77 N109 F110 G111 D113
External links
PDB RCSB:8fyu, PDBe:8fyu, PDBj:8fyu
PDBsum8fyu
PubMed37645969
UniProtQ9UNE7|CHIP_HUMAN E3 ubiquitin-protein ligase CHIP (Gene Name=STUB1)

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