Structure of PDB 8fyf Chain B

Receptor sequence
>8fyfB (length=387) Species: 9606 (Homo sapiens) [Search protein sequence]
IQCSQRMLSFSDALLSIIATVMILPVTHTEISPEQQFDRSVQRLLATRIA
VYLMTFLIVTVAWAAHTRLFQVVGKTDDTLALLNLACMMTITFLPYTFSL
MVTFPDVPLGIFLFCVCVIAIGVVQALIVGYAFHFPHLLSPQIQRSAHRA
LYRRHVLGIVLDLHEPLSKERVEAFSDGVYAIVATLLILDICEDNVPDPK
DVKERFSGSLVAALSATGPRFLAYFGSFATVGLLWFAHHSLFLHVRKATR
AMGLLNTLSLAFVGGLPLAYQQTSAFARQPRDELERVRVSCTIIFLASIF
QLAMWTTALLHQAETLQPSVWFGGREHVLMFAKLALYPCASLLAFASTCL
LSRFSVGIFHLMQIAVPCAFLLLRLLVGLALATLRVL
3D structure
PDB8fyf Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B F384 L391 L398 L399 F411 H416 F420 F434 F295 L302 L309 L310 F322 H327 F331 F345
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0015252 proton channel activity
GO:0022841 potassium ion leak channel activity
GO:0050544 arachidonate binding
Biological Process
GO:0035751 regulation of lysosomal lumen pH
GO:0035752 lysosomal lumen pH elevation
GO:0070050 neuron cellular homeostasis
GO:0071805 potassium ion transmembrane transport
GO:0090385 phagosome-lysosome fusion
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0010008 endosome membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fyf, PDBe:8fyf, PDBj:8fyf
PDBsum8fyf
PubMed37390818
UniProtQ9BSA9|TM175_HUMAN Endosomal/lysosomal proton channel TMEM175 (Gene Name=TMEM175)

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