Structure of PDB 8ftm Chain B

Receptor sequence
>8ftmB (length=731) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
MRARLIPPMDVLHQAILEWDIFHEGCGNVSDTYPDPYSYKQTFFPLLINE
AWRSFVTAKDETTSKPFGIKVLSRMTVDKFMEVTAAVPAQISKDRGLTEG
DIVIISKGEDPLNQPQELHCLSRIWKTTYKKDTVEVVYRLNAKGNQILPA
LTPGSEFQVVKITNMTTIEREYAALESLQYYDLMDEILKAQPSPMLTFGD
EAIKAVMDNYQLNPGQARAILNAKENDGFTLIQGPPGTGKTKTIVAMVGC
LLTGVLPSKKLLVCAPSNAAVDELVLRLKAGVKTMNGTFHKIEVLRLGRS
DVINAAVKDVTLDELVKARMDAELSKNSSPSERDQLHKEAGEIKAKLAEI
RPQLDAARLSDDRASAMKLQREFDELKRRQAHIGAKIDADKASGNTYARE
TEIKRRQIQQEILDKAQVLCATLSGSGHEMFKNLNVEFETVIIDEAAQCV
ELSALIPLKYGCNKCILVGDPKQLPPTVLSQSAAKYGYDQSLFVRMQKNH
PKDVHLLDMQYRMHPEISRFPSKEFYEGLLQDGADMARLRLQPWHQSVLL
GPYRFFDVKGSQERGPKNQSLVNEEEVKVAMQLYMRFRSDYRDIDLTGKI
GIITPYKAQLQRLRQKFVERYGESITEQIEFNTTDAFQGRECEIIIFSCV
RASPTGGIGFMTDIRRMNVGLTRARSSLWILGDSRALVQGEFWAKLIEDA
KQRDRYTNGNIMALLSQPGPRVSLESLAKQY
3D structure
PDB8ftm Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2.
ChainB
Resolution3.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B T1273 R1276 P1394 S1395 N1396 G1426 R1427 D1441 T1550 H1556 M1558 T1605 L1607 Q1609 S1698 Y1734 K1735 T1761 D1763 G1787 F1788 T167 R170 P266 S267 N268 G298 R299 D313 T422 H428 M430 T477 L479 Q481 S570 Y606 K607 T633 D635 G659 F660
Gene Ontology
Molecular Function
GO:0004386 helicase activity

View graph for
Molecular Function
External links
PDB RCSB:8ftm, PDBe:8ftm, PDBj:8ftm
PDBsum8ftm
PubMed37832548
UniProtG0S163

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