Structure of PDB 8fhi Chain B

Receptor sequence
>8fhiB (length=610) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
DWEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGA
VGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMN
QNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEE
IVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSD
LQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLY
DLTEIDSWGEELSFLELVVSSKKREARQILEQTPVKELVSFKWKKYGRPY
FCVLASLYILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYV
THQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVI
IITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPF
TIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPT
ALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMM
GDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGYEYGLGDR
WFLRVENHHD
3D structure
PDB8fhi Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A.
ChainB
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ERG B C556 A560 C528 A532
BS02 ERG B P424 F425 F456 V459 T479 Q483 F487 P396 F397 F428 V431 T451 Q455 F459
BS03 ERG B M497 P527 M469 P499
BS04 3VV B F416 G417 P424 V427 K484 F487 F388 G389 P396 V399 K456 F459
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005516 calmodulin binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0035809 regulation of urine volume
GO:0051289 protein homotetramerization
GO:0055074 calcium ion homeostasis
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0098703 calcium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Cellular Component
External links
PDB RCSB:8fhi, PDBe:8fhi, PDBj:8fhi
PDBsum8fhi
PubMed37735536
UniProtQ9XSM3|TRPV5_RABIT Transient receptor potential cation channel subfamily V member 5 (Gene Name=Trpv5)

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