Structure of PDB 8fhg Chain B

Receptor sequence
>8fhgB (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDSPFVIYDMN
SLMMGEDKIKFKHSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLD
LNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQ
DNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTE
TDMSLHPLLQEIYKDLY
3D structure
PDB8fhg Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and ZINC5672437
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V293 T297 K301 L311 Q314 L318 K319 H323 V83 T87 K91 L101 Q104 L108 K109 H113
BS02 XZK B I281 F282 C285 Q286 H323 F363 M364 K367 H449 Y473 L476 Y477 I71 F72 C75 Q76 H113 F153 M154 K157 H239 Y263 L266 Y267
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fhg, PDBe:8fhg, PDBj:8fhg
PDBsum8fhg
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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