Structure of PDB 8fhe Chain B

Receptor sequence
>8fheB (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDM
NSLMMGEDKKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQV
TLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFME
PKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQ
ALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSL
HPLLQEIYKDLY
3D structure
PDB8fhe Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and GW9662
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B T297 K301 V315 L318 K319 H323 T82 K86 V100 L103 K104 H108
BS02 GW9 B F282 C285 Q286 H323 F363 K367 H449 Y473 L476 Y477 F67 C70 Q71 H108 F148 K152 H234 Y258 L261 Y262
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fhe, PDBe:8fhe, PDBj:8fhe
PDBsum8fhe
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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