Structure of PDB 8fh3 Chain B

Receptor sequence
>8fh3B (length=1152) Species: 9606 (Homo sapiens) [Search protein sequence]
MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLK
GHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVS
YNPITHQLASCSSSDFGLWSPEQKSVSKHKSSSKIICCSWTNDGQYLALG
MFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSSRWESFWMNREIQ
EIPSTLKNLEERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISY
FTKGEYILLGGSDKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVV
GCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCK
ELVKKIAIYRNRLAIQLPEKILIYELYSEDLSDMHYRVKEKIIKKFECNL
LVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGL
LVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTC
LVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQ
KLQGFVVGYNGSKIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIAC
LGVTDTDWRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIEERKKRG
ETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDF
LGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKAIEICGDHG
WVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLV
QLHVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKA
GRQREAVQVLEQLTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTM
LGKFYHFQRLAELYHGYHAIHRHTEDPFSVHRPETLFNISRFLLHSLPKD
TPSGISKVKILFTLAKQSKALGAYRLARHAYDKLRGLYIPARFQKSIELG
TLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSY
DVLHLVEFYLEEGITDEEAISLIDLESEFVPVVVSRLVLRSMSRRDVLIK
RWPPPLRWQYFRSLLPDASITMCPSCFQMFHSEDYELLVLQHGCCPYCRR
CK
3D structure
PDB8fh3 Human IFT-A complex structures provide molecular insights into ciliary transport.
ChainB
Resolution4.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1057 C1074 C1019 C1036
BS02 ZN B C1207 C1229 C1232 C1123 C1145 C1148
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0001843 neural tube closure
GO:0010172 embryonic body morphogenesis
GO:0021513 spinal cord dorsal/ventral patterning
GO:0030030 cell projection organization
GO:0035050 embryonic heart tube development
GO:0035115 embryonic forelimb morphogenesis
GO:0035556 intracellular signal transduction
GO:0035720 intraciliary anterograde transport
GO:0035721 intraciliary retrograde transport
GO:0042073 intraciliary transport
GO:0045879 negative regulation of smoothened signaling pathway
GO:0048593 camera-type eye morphogenesis
GO:0060173 limb development
GO:0060271 cilium assembly
GO:0060971 embryonic heart tube left/right pattern formation
GO:0061512 protein localization to cilium
GO:0072594 establishment of protein localization to organelle
GO:1905515 non-motile cilium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0016020 membrane
GO:0030991 intraciliary transport particle A
GO:0032391 photoreceptor connecting cilium
GO:0036064 ciliary basal body
GO:0097542 ciliary tip
GO:0097730 non-motile cilium

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fh3, PDBe:8fh3, PDBj:8fh3
PDBsum8fh3
PubMed36775821
UniProtQ9HBG6|IF122_HUMAN Intraflagellar transport protein 122 homolog (Gene Name=IFT122)

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