Structure of PDB 8feg Chain B

Receptor sequence
>8fegB (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
PAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALAD
ALVTTTMPFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVD
RYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVRDVI
ECSLQFPDSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSG
SREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSS
YYFCIALGYTNSCLNPILYAFLDENFKR
3D structure
PDB8feg Cryo-EM structure of KOR bound to G protein complex and a peptide ligand
ChainB
Resolution2.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Q115 V118 V134 C210 F293 E297 T302 S303 S305 A308 L309 Y312 Q60 V63 V79 C152 F232 E236 T241 S242 S244 A247 L248 Y251
BS02 XT9 B D138 V230 I290 I294 Y312 I316 Y320 D83 V169 I229 I233 Y251 I255 Y259
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004985 G protein-coupled opioid receptor activity
GO:0038048 dynorphin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8feg, PDBe:8feg, PDBj:8feg
PDBsum8feg
PubMed38052802
UniProtP41145|OPRK_HUMAN Kappa-type opioid receptor (Gene Name=OPRK1)

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