Structure of PDB 8fbg Chain B

Receptor sequence

>8fbgB (length=218) Species: 10090 (Mus musculus) [Search protein sequence]

KKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINR
MLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKK
GEFVNECVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGN
YARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLG
NGKTVCKCGAPNCSGFLG

3D structure

PDB

8fbg Crystal structure of NSD1

Chain

Resolution

2.29 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.357: [histone H3]-lysine(36) N-dimethyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	B	C1921 C1968 C1970 C1975	C159 C206 C208 C213
BS02	ZN	B	C1793 C1795 C1803 C1809	C31 C33 C41 C47
BS03	ZN	B	C1803 C1818 C1829	C41 C56 C67
BS04	ZN	B	C1793 C1818 C1823	C31 C56 C61
BS05	SAM	B	R1850 G1851 W1852 T1892 N1893 F1894 Y1895 R1915 F1916 N1918 H1919 Y1956 N1963 C1968 L1979	R88 G89 W90 T130 N131 F132 Y133 R153 F154 N156 H157 Y194 N201 C206 L217
BS06	CA	B	R1792 C1793 C1818 H1819 C1823	R30 C31 C56 H57 C61

Gene Ontology

	Molecular Function
GO:0042054	histone methyltransferase activity

	Cellular Component
GO:0005634	nucleus

View graph for
Molecular Function

View graph for
Cellular Component

External links

PDB	RCSB:8fbg, PDBe:8fbg, PDBj:8fbg
PDBsum	8fbg
PubMed
UniProt	O88491\|NSD1_MOUSE Histone-lysine N-methyltransferase, H3 lysine-36 specific (Gene Name=Nsd1)

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