Structure of PDB 8f8z Chain B

Receptor sequence
>8f8zB (length=433) Species: 9606 (Homo sapiens) [Search protein sequence]
NMATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYH
CPNCEKTHGKSTLKKVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLG
YMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTK
QKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLS
WVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEK
TFYLIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIP
SGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNF
ETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALA
EHEDELPEHFKPSQLIKDLAKEIRLSENASKAV
3D structure
PDB8f8z A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2.
ChainB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y14 T17 F19 M20 I21 E22 W29 E39 I45 D46 Y145 E150 V178 D179 Y182 Y15 T18 F20 M21 I22 E23 W30 E40 I46 D47 Y129 E134 V162 D163 Y166
BS02 ZN B C23 C26 C50 C53 C24 C27 C51 C54
BS03 ZN B C8 H31 C34 C9 H32 C35
External links
PDB RCSB:8f8z, PDBe:8f8z, PDBj:8f8z
PDBsum8f8z
PubMed36596360
UniProtO75151|PHF2_HUMAN Lysine-specific demethylase PHF2 (Gene Name=PHF2)

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