Structure of PDB 8f8y Chain B

Receptor sequence
>8f8yB (length=433) Species: 9606 (Homo sapiens) [Search protein sequence]
NMATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYH
CPNCEKTHGKSTLKKVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLG
YMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTK
QKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLS
WVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEK
TFYLIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIP
SGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNF
ETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALA
EHEDELPEHFKPSQLIKDLAKEIRLSENASKAV
3D structure
PDB8f8y A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2.
ChainB
Resolution3.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y14 F19 M20 I21 E22 W29 E39 I45 Y145 E150 V178 D179 Y182 Y15 F20 M21 I22 E23 W30 E40 I46 Y129 E134 V162 D163 Y166
BS02 ZN B C23 C26 C50 C53 C24 C27 C51 C54
BS03 ZN B C8 H31 C34 C9 H32 C35
External links
PDB RCSB:8f8y, PDBe:8f8y, PDBj:8f8y
PDBsum8f8y
PubMed36596360
UniProtO75151|PHF2_HUMAN Lysine-specific demethylase PHF2 (Gene Name=PHF2)

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