Structure of PDB 8f7u Chain B

Receptor sequence
>8f7uB (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
AAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGT
LISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLE
PTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGT
FGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDA
GGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
3D structure
PDB8f7u Synthesis and structural characterization of new macrocyclicplasmin inhibitors
ChainB
Resolution1.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.7: plasmin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GGI B F583 G584 M585 T688 Q689 G690 F692 F42 G43 M44 T147 Q148 G149 F151
BS02 GGI B H603 D646 R719 Q721 E724 D735 S736 C737 Q738 T759 S760 W761 G762 G764 C765 H62 D105 R178 Q180 E183 D194 S195 C196 Q197 T218 S219 W220 G221 G223 C224
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8f7u, PDBe:8f7u, PDBj:8f7u
PDBsum8f7u
PubMed
UniProtP00747|PLMN_HUMAN Plasminogen (Gene Name=PLG)

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